Sepsis is a major cause of mortality. Therefore, early detection of sepsis is of high importance. Antibiotics constitute a powerful antidote. However, the application of antibiotics without need, i.e. for purely risk reduction in general, has side effects in antibiotics losing their effectiveness later on.
The paper published in The Lancet Digital Health by van der Weijden et al. (2024) reports on the effort to provide an open source access to a calculator of early onset of sepsis (Link). The Neonatal early-onset sepsis calculator developed by Kaiser Permanente builds on the use on the risk carried by mothers like time since membrane rupture, regional infection risks of mothers per 1000 population and the infants presentation at birth. It is important to point out the combination of risks put into the calculator. New systems of artificial intelligence might equally make predictions or recommendations about the application of antibiotics implicitly making use of such a calculator without disclosure.
From a sociological point of view it is interesting to scrutinize the indicators used in the calculation. The approximation of mothers carrying a sepsis risk relies on national, regional or better local indicators. This information is rarely accessible to the public. The choice of a hospital, speed of access to it in case of membrane rupture as well as staffing come into the calculation of an overall risk of sepsis.
It is great to follow the progress of digital health and the increased transparency of critical health decisions at the earliest stages of the life course. Inflammation as a precursor of sepsis should be taken serious at all stages of the life course. (Image calculation based on Kaiser Permanente digital tool Link)