Mammals share a lot of similarities with respect to aging. The researchers Alexander Tyshkovskiy and Vadim N. Gladyshev et al. (2026) spearheaded multiple research to identify similarities across humans, macaques, rodents and mice. The outcome of this overarching study of mammalian aging and mortality is a set of biomarkers that can serve to predict time to death.
Why is this interesting? With the rise of the longevity interest in the 21st century, the need increases to use robust biomarkers that can assess any presumably miraculous innovation to smooth human aging or prolong the time to death. Steps towards “universal transcriptomic signatures” including CDKN1A and LGALS3 (compare across species), which proved to be important in mortality predictions based on the large UK Biodata.
It is the accumulation of damage, which drives processes of aging . However, “inflammation, replicative senescence, metabolic inhibition and γ-irradiation” can be attenuated or occasionally even reversed. The aging of cellular components has been demonstrated using “modular-specific clocks”.
With these biological advances in the field of biomarkers, the BPS nexus (biology-psychology-society links) could receive more attention as well in order to enlarge the society-wide research into the causes of human aging.
(Image: Staatsballett Berlin, Choreographie Crystal Pite, Gods and Dogs, Angels’ Atlas performed 2026-5, final applause)
